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WORLDCOMP'09/PDPTA'09 Keynote - Professor P. M. A. Sloot

Last modified 2009-03-01 01:26

Sex and the City: Modelling HIV from Molecule to Man
Prof. P. M. A. Sloot
Scientific Director of the Institute for Informatics,
Professor of Computational Sciences, University of Amsterdam, The Netherlands,
Editor-in-Chief, Future Generation Computer Systems (Elsevier Science Publishers)

Date: July 13, 2009
Time: 6:00pm - 8:00pm
Location: TBA


    Human Immunodeficiency Virus (HIV) is recognized to be one of the most destructive pandemics in recorded history. Effective highly active antiretroviral therapy (HAART) and the availability of genetic screening of patient virus data, has led to sustained viral suppression and higher life expectancy in patients who have been infected with HIV. The sheer complexity of the disease stems from the multi-scale and highly dynamic nature of the system under study. The complete cascade from genome, proteome, metabolome and physiome to health forms a multidimensional system that crosses many orders of magnitude in temporal and spatial scales. Understanding, quantifying and handling this complexity is one of the biggest challenges of our time, which requires a highly multidisciplinary approach. In order to supply researchers with an interactive framework and to provide the medical professional with appropriate tools and information for making a balanced and reliable medication decision, we have developed “ViroLab”, a collaborative decision support system ( ViroLab contains computational models that cover various spatial and temporal scales from atomic level interactions in nanoseconds up to sociological interactions on the epidemiological level, spanning years of disease progression.

    Moreover, ViroLab allows for personalized drug ranking. It is on trial in six hospitals and various virology and epidemiology laboratories across Europe.


    Shan Mei, P.M.A Sloot, Rick Quax, David van de Vijver, Yifan Zhu, 'Complex Agent Networks explaining the HIV epidemic among homosexual men in Amsterdam'. In press. link:

    Rick Quax, David A. Bader, and Peter M.A. Sloot, 'Simulating Individual-Based Models of Epidemics in Hierarchical Networks' Submitted.

    Sloot, P.M.A., Boukhanovsky, A.V., Keulen, W., Tirado-Ramos, A., Boucher, C.A. October 2005 A Grid-based HIV expert system. Journal of Clinical Monitoring and Computing 19 (4-5) : 263-78. ISSN: 11387-1307

    Sloot, P.M.A., Chen, F., Boucher, C. 2002 Cellular Automata Model of Drug Therapy for HIV Infection. In S. Bandini, & B. T. Chopard (Ed.), 5th International Conference on Cellular Automata for Research and Industry. 2493, pp. 282-293. Geneva: Lecture Notes in Computer Science.

    Sloot, P.M.A, Ivanov, S., Boukhanovsky, A., van de Vijver, D., & Boucher, C. 2008 Stochastic Simulation of HIV Population Dynamics through Complex Network Modeling. Intermational Journal of Computer Mathematics , 85 (8), 1175-1187.

    Sloot, P.M.A., Tirado-Ramos, A., Altintas, I., Bubak, M.T. and Boucher, C.A. November 2006 From Molecule to Man: Decision Support in Individualized E-Health. IEEE Computer, (Cover feature) 39 (11), 40-46.

    P.M.A. Sloot; P.V. Coveney; M.T. Bubak; A.-M. Vandamme; B. Ó Nualláin; D. van de Vijver and C.A.B. Boucher: Virolab: A Collaborative Decision Support System in Viral Disease Treatment, Reviews in Antiviral Therapy, vol. 3, pp. 4-7. Virology Education, 2008. ISSN 1872-437X.


    Prof. Peter M.A. Sloot studied chemistry and physics, finished his Computational BioPhysics PhD work at the Dutch Cancer institute did various postdoctoral contracts abroad. In 1996 he was appointed on the prestigious chair in Computational Physics from the Dutch Physics Society and is since 2001 he is a full professor in Computational Sciences. In his research, he focuses on the theory and application of complex systems through distributed mesoscopic computer simulation; trying to understand how information progresses through various spatial and temporal scales. He is strongly interested in applying his idea’s to BioMedical systems. Dr. Sloot published over 450 papers in International Journals.

Academic Co-Sponsors

United States Military Academy, Network Science Center

Biomedical Cybernetics Laboratory, HST of Harvard University and MIT, USA

Argonne's Leadership Computing Facility of Argonne National Laboratory

Functional Genomics Laboratory, University of Illinois at Urbana-Champaign, USA
Minnesota Supercomputing Institute, University of Minnesota, USA
Intelligent Data Exploration and Analysis Laboratory, University of Texas at Austin, Austin, Texas, USA
Harvard Statistics Department Genomics & Bioinformatics Laboratory, Harvard University, USA

Texas Advanced Computing Center, The University of Texas at Austin, Texas

Center for the Bioinformatics and Computational Genomics, Georgia Institute of Technology, Atlanta, Georgia, USA

Bioinformatics & Computational Biology Program, George Mason University, Virginia, USA

Institute of Discrete Mathematics and Geometry, Vienna University of Technology, Austria

BioMedical Informatics & Bio-Imaging Laboratory, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
Knowledge Management & Intelligent System Center (KMIS) of University of Siegen, Germany

National Institute for Health Research, UK

Hawkeye Radiology Informatics, Department of Radiology, College of Medicine, University of Iowa, Iowa, USA

Institute for Informatics Problems of the Russian Academy of Sciences, Moscow, Russia.
Medical Image HPC & Informatics Lab (MiHi Lab), University of Iowa, Iowa, USA
SECLAB An inter-university research group (University of Naples Federico II, the University of Naples Parthenope, and the Second University of Naples, Italy)
The University of North Dakota, Grand Forks, North Dakota, USA
Intelligent Cyberspace Engineeing Lab., ICEL, Texas A&M; University (Com./Texas)

International Society of Intelligent Biological Medicine

World Academy of Biomedical Sciences and Technologies

Corporate Sponsor

Other Co-Sponsors
European Commission
High Performance Computing for Nanotechnology (HPCNano)

HoIP - Health without Boundaries

Hodges' Health

The International Council on Medical and Care Compunetics

GridToday - enewsletter focused on Grid, SOA, Virtualization, Storage, Networking and Service-Oriented IT

HPCwire - The Leading Source for Global News and Information Covering the Ecosystem of High Productivity Computing

The UK Department for Business, Enterprise & Regulatory Reform
VMW Solutions Ltd.
Scientific Technologies Corporation

Bentham Science Publishers


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